Fungal infections are rising, with over 1.5 billion cases and more than 1 million deaths recorded each year.Among these, Candida infections are frequent in at-risk populations and the rapid development of drug resistance and tolerance contributes to their clinical persistence.Few antifungal drugs are available, and their efficacy is declining due t
The Multiminerals effectiveness of topical application of various drugs in ophthalmology is no more than 3 % due to the presence of anatomical and physiological barriers.The therapeutic effect accomplishment is possible with increasing concentration or multiplicity of drug use.The article presents the results of the development of a new type of the
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is among the cancer types with poorest prognosis and survival rates primarily due to resistance to standard-of-care therapies, including gemcitabine (GEM) and olaparib.Particularly, wild-type (wt)BRCA tumours, the most prevalent in Accessories PDAC, are more resistant to DNA-targeting agen
In the cybersecurity industry, where legitimate transactions far outnumber fraudulent ones, detecting fraud is of paramount significance.In order to evaluate the accuracy of detecting fraudulent transactions in imbalanced real datasets, this study compares the efficacy of two approaches, random under-sampling and oversampling, using the synthetic m